Cysteine proteases of pathogenic organisms
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Cysteine proteases of pathogenic organisms by Mark W. Robinson

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Published by Springer Science+Business Media, Landes Bioscience in New York, Austin, Tex .
Written in English

Subjects:

  • Cysteine proteinases,
  • Cysteine Proteases,
  • Pathogenic microorganisms,
  • Eukaryota,
  • Pathophysiology,
  • Microbial enzymes,
  • Enzymology,
  • Viruses,
  • Immunology,
  • Chemistry,
  • Bacteria

Book details:

About the Edition

Cysteine proteases expressed by pathogenic organisms play key roles in virulence including host entry, feeding and suppression of host immune responses. This book gives comprehensive coverage to all aspects of pathogen cysteine proteases and brings together numerous scientific advances which have been made over many years. Thus, the biochemistry, molecular biology and structure function relationships of these important pathogen enzymes are covered in detail. Written by leading researchers from Europe, Australia and North America, this book is essential reading for students and professionals interested in human medicine and infectious disease research --Provided by publisher.

Edition Notes

Statementedited by Mark W. Robinson, PhD, Infection, Immunity and Innovation (i3) Institute, University of Technology Sydney, Ultimo, Sydney, Australia, John P. Dalton, PhD, Institute of Parasitology, McDonald Campus, McGill University, St. Anne de Bellevue, Quebec, Canada
SeriesAdvances in experimental medicine and biology -- v. 712, Advances in experimental medicine and biology -- v. 712.
Classifications
LC ClassificationsQP609.C94 C965 2011
The Physical Object
Paginationxix, 226 pages :
Number of Pages226
ID Numbers
Open LibraryOL25255650M
ISBN 101441984135
ISBN 109781441984135
LC Control Number2010050245
OCLC/WorldCa688679726

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Cysteine Proteases of Pathogenic Organisms by Mark W. Robinson, , available at Book Depository with free delivery worldwide. Cysteine proteases expressed by pathogenic organisms play key roles in virulence including host entry, feeding and suppression of host immune responses. Written by leading researchers from Europe, Australia and North America, this book is essential reading for students and professionals interested in human medicine and infectious disease research. Summary: Cysteine proteases expressed by pathogenic organisms play key roles in virulence including host entry, feeding and suppression of host immune responses. This book gives comprehensive coverage to all aspects of pathogen cysteine proteases and brings together numerous scientific advances which have been made over many years. Description: Cysteine proteases expressed by pathogenic organisms play key roles in virulence including host entry, feeding and suppression of host immune responses. This book gives comprehensive coverage to all aspects of pathogen cysteine proteases and brings together numerous scientific advances which have been made over many years.

A number of cysteine proteases of malaria parasites have been described and many more are suggested by analysis of the Plasmodium falciparum genome sequence. The best characterized of these proteases are the falcipains, a family of four papain-family enzymes.   The YopT cysteine protease family YopT family: protease classification. The YopT family shares secondary structure with cysteine proteases (; Table 1). These effectors belong to the C58 family in the CA clan. At present, this family has 19 known members, all from pathogenic and symbiotic bacteria.   Cysteine proteases play important role in life cycle of parasitic organism. Parasites also express cathepsin L and B like proteases. Falcipains, well characterized cathepsin L-like cysteine proteases from P. falciparum, synthesize as zymogens and get activated by auto activation in acidic environment (pH 5–). Cysteine proteases, also known as thiol proteases, are enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad. Cysteine proteases are commonly encountered in Missing: book.

To establish infection, pathogens deliver effectors into host cells to target immune signaling components, including elements of mitogen-activated protein kinase (MPK) cascades. The virulence function of AvrRpt2, one of the first identified Pseudomonas syringae effectors, involves cleavage of the plant defense regulator, RPM1-INTERACTING PROTEIN4 (RIN4), and interference with plant auxin.   Cysteine Proteases is one of proteases enzyme that cleave protein by cleave the peptide bond. The strategy used by the cysteine proteases is most similar to that use to be chymotrypsin family that is to generate a nucleophile that attack the peptide carbonyl group. Plant protease inhibitors are diverse in number and in specificity towards various proteolytic enzymes. This book focuses on the isolation, structure, characterization, physiochemical and physiological properties, synthesis, functions and mechanisms of action of plant protease inhibitors. It deals with their inhibitory effects on insects and pathogens and with their induction and introduction.   Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites, including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or modulation of the host immune response, making them attractive chemotherapeutic and vaccine targets. This review highlights current knowledge on clan CA cysteine proteases, the best-characterized .